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4WZ6 Contains 37% helical (14 helices) 18% beta sheet (11 beta sheets). This image shows the common mutation in cystic fibrosis (CF) patients, the deletion of F508 (delta F508) in the first nucleotide binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR).Researchers are trying to find a path may exist to deltaF508 CFTR correction through a small molecule chaperone binding to NBD1. They have set out to find small molecule binders of NBD1 and test if it is possible to develop these molecules into potent binders that increase CFTR trafficking in CF-patient Hall, J.D., Wang, H., Byrnes, L.J., Shanker, S., Wang, K., Efremov, I.V., Chong, P.A., Forman-Kay, J.D., Aulabaugh, A.E. Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy. (2016) Protein Sci. 25: 360-373 (PubMed) 4WZ6 (PDB) |